Content Determination of Magnesium in Esomeprazole Magnesium by Inductive Coupled Plasma Atomic E-mission Spectrometry
- VernacularTitle:电感耦合等离子体原子发射光谱法测定艾司奥美拉唑镁中镁的含量
- Author:
Yingyan JIANG
;
Zhipeng GENG
;
Yan LIU
;
Qi YANG
;
Haixia YANG
- Keywords:
Esomeprazole magnesium;
Magnesium;
Content determination;
Inductive coupled plasma atomic emission spectrome-try
- From:
China Pharmacist
2017;20(1):154-155,156
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method for the content determination of magnesium in esomeprazole magnesium. Methods:The content of magnesium in esomeprazole magnesium was determined by inductive coupled plasma atomic emission spectrometry. Re-sults:The linear range was 10.0-80.0 μg·ml-1(r=0.999 8). The average recovery was 99.55% with RSD of 1.35% (n=9). The detection limit was 0. 000 75 μg·ml-1 and the quantitative limit was 0. 002 5 μg·ml-1 . Conclusion:The method is accurate, sensitive and reproducible, which can be used for the content determination of magnesium in esomeprazole magnesium.
