Anti-rheumatoid Arthritis Activity and Mechanism of Erteng Tongbi Granule

VernacularTitle:二藤通痹颗粒抗类风湿关节炎活性和机制研究
Author: Zhiqiang SU ; Chengliang ZHANG
Keywords: Erteng Tongbi granule; Rheumatoid arthritis; Anti-inflammation
From: China Pharmacist 2017;20(1):32-34,35
CountryChina
Language:Chinese
Abstract: Objective:To discuss the anti-rheumatoid arthritis activity and mechanism of hospital preparation Erteng Tongbi gran-ule ( ETTB) . Methods:The collagen-induced arthritis ( CIA) animal model in DBA/1 mice was established and treated with high, medium and low dosage of ETTB. Blank control, model control and methotrexate group were also established. The influences of ETTB on BMI, arthritis index, ankle joint destruction and expression of serum cytokine TNF-α and IL-6 in CIA mice were observed. Re-sults:Compared with the control group, ETTB at high dose (6g?kg-1) could significantly decrease the arthritis index of CIA mice (P<0. 05), and the joint damage on the 14th day was also significantly improved. ELISA results showed that ETTB at high dose could significantly inhibit the secretion of cytokine TNF-αand IL-6 when compared with the model group (P<0. 01). Conclusion:Hospital preparation ETTB has anti-rheumatoid arthritis activity, and its mechanism may be related with the inhibition of cytokine secretion.