Application of hepatitis C virus core antigen detection in hepatitis C Screening
10.3969/j.issn.1673-4130.2017.04.014
- VernacularTitle:丙型肝炎病毒核心抗原检测在丙型肝炎筛检中的应用
- Author:
Qingyin LIU
;
Xiaoqing LIU
;
Huaxin LI
- Keywords:
viral hepatitis C;
hepatitis C virus core antigen;
screening
- From:
International Journal of Laboratory Medicine
2017;38(4):468-469,472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of HCV core antigen (HCV-cAg )in hepatitis C screening. Methods From October 2014 to October 2015 ,a total of 8000 serum samples were collected from the outpatient and inpatient. HCV-cAg and hepatitis C antibody (HCV-Ab) were detected by using ELISA.The positive samples of HCV-cAg or HCV-Ab were performed the confirmative diagnostic detection by PCR.Results Among 8000 serum samples ,82 positive samples were screened out ,in which 73 cases were HCV-RNA positive by elementary screening with the standard of HCV-cAg or HCV-Ab positive ,a-mong which 72 were HCV-RNA positive and and 9 cases were HCV-RNA negative by HCV-RANA confirmation.The sensitivity and specificity of HCV-cAg were 45.83% and 99.98% ,sensitivity and specificity of HCV-Ab were 94.44% and 99.90% ,which of HCV-cAg and HCV-Ab combined detection were 100.00% and 98.86% respectively.Conclusion HCV-cAg and HCV-Ab play complementary role in HCV screening.Their combined detecting contributes to increase the screening rate of HCV.
