Analysis on relationship between MTHFR C677T locus polymorphism and unexplained adverse pregnancy by gene chip method
10.3969/j.issn.1673-4130.2017.04.016
- VernacularTitle:基因芯片法分析MTHFR基因C677T还原酶位点多态性与原因不明不良孕产的关系
- Author:
Zhengmin SUN
;
Hua WANG
;
Dong FENG
- Keywords:
unexplained;
adverse pregnancy;
allele
- From:
International Journal of Laboratory Medicine
2017;38(4):473-474,477
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between 5 ,10-methylenetetrahydrofolate reductase (MTHFR) gene C677T locus polymorphism and unexplained adverse pregnancy.Methods Three hundreds and twenty pregnant women with unknown ad-verse pregnancy ≥ 2 times in the infertility department ,and obstetrics and gynecology department of our hospital from June 2014 to May 2016 were selected as the case group and 388 healthy non-abortion parous women were taken as the control group.The MTH-FR gene C677T locus polymorphism in the two groups was analyzed by using gene chip method.The differences in genotype and al-lele frequency distribution were compared between the two groups ,and the relationship between unexplained adverse pregnancy and MTHFR C677T locus polymorphism was analyzed.Results The frequency distribution of MTHFR genotype C677T C/C had sta-tistically significant difference between the case group and control group (P<0.05 ,OR=0.284).The frequency distribution of gen-otype C/T had no statistical difference between the case group and control group (P=0.400 ,OR=1.140).The frequency distribu-tion of genotype T/T had statistical difference between the case group and control group (P<0.05 ,OR=7.672).The frequency distribution of allele C and T had statistical difference between the case group and control group ( P< 0.05 ,OR= 0.304 ). Conclusion The high expression of MTHFR C677T genotype T/T may be a risk factor of unknown adverse pregnancy in child-bearing age women.
