Analysis on detection of Hcy ,vWf and TF-PCA within 48 h of onset in patients with coronary heart disease
10.3969/j.issn.1673-4130.2017.04.020
- VernacularTitle:冠心病患者发病48h内同型半胱氨酸、血管性血友病因子和组织因子促凝活性的检测分析
- Author:
Jun LIU
;
Danxin DU
;
Jia LIU
;
Mingjie ZHANG
- Keywords:
acute myocardial infarction;
stable angina pectoris;
homocysteine;
von willebrand factor;
tissue factor pro-coagulant activity
- From:
International Journal of Laboratory Medicine
2017;38(4):483-484,487
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change of serum homocysteine (Hcy) ,plasma von willebrand factor (vWF) and whole blood tissue factor procoagulant activity (TF-PCA) within 48 h of onset in the patients with coronary heart disease (CHD).Meth-ods The relevant instrument was adopted to detect the level of serum Hcy ,plasma vWF and whole blood TF-PCA in 300 CHD pa-tients and 100 individuals undergoing the healthy physical examination ,and then the statistical analysis was performed.Three hundreds cases of CHD were divided into the stable angina group (SAP group ,n= 96) ,unstable angina group (UAP group ,n=100) and acute myocardial infarction group (AMI group ,n=104).Results The Hcy ,vWF and TF-PCA levels in the CHD patients were higher than those in the control group ,the difference was statistically significant (P<0.05).The Hcy level:the AMI group>UAP group> SAP group ,the difference was statistically significant (P<0.05).The vWF and TF-PCA levels in the AMI group and UAP group were higher than those in the SAP group with statistical difference (P<0.05).The Hcy level in SAP ,UAP and AMI patients complicated with diabetes and hypertension was significantly increased compared with the patients without complicating di-abetes and hypertension ,the difference was statistically significant (P<0.05).The vWF and TF-PCA levels had statistical differ-ence between the UAP group and AMI group(P<0.05).Conclusion Routinely detecting the levels of Hcy ,vWF and TF-PCA has an important clinical value for the diagnosis and curative effect observation in the patients with CHD.
