Preparation of Paeonol-HP-β-cyclodextrin Inclusion Compound and Its Prescription Technology Optimiza-tion

VernacularTitle:丹皮酚-羟丙基-β-环糊精包合物的制备及处方工艺优化
Author: Xin ZHENG ; Peihong YANG ; Lin HE ; Xi CHEN ; Mo CHENG ; Bibo YOU
Keywords: Paeonol; HP-β-CD; Inclusion compound; Central composite design-response surface methodology; Prescription technology; Optimization
From: China Pharmacy 2017;28(4):530-532,533
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To prepare paeonol-HP-β-cyclodextrin (PAE-HP-β-CD) inclusion compound and to optimize its pre-scription technology. METHODS:PAE-HP-β-CD was prepared by freeze drying method and validated. Using inclusion rate as in-dex,main drug-accessory ratio,inclusion time,inclusion temperature and stirring speed as factors,the preparation technology was optimized by central composite design-response surface methodology. RESULTS:Prepared PAE-HP-β-CD underwent phase transfor-mation. The optimal inclusion technology was as follows as main drug-accessory ratio of 3.39∶1,inclusion temperature of 50 ℃, inclusion time of 3.2 h, stirring speed of 350 r/min. Relative error between measured value (87.46%) and predicted value (89.12%) of inclusion rate was 1.86%(n=6). CONCLUSIONS:PAE-HP-β-CD inclusion compound is prepared successfully, and its prescription technology is stable and feasible.