Expressions and clinical significance of CD146 and TfR1 in ovarian epithelial cancer
10.7652/jdyxb201701022
- VernacularTitle:CD146和TfR1在上皮性卵巢癌中的表达及临床意义
- Author:
Qianqian GE
;
Xiuqin CHEN
;
Qi GUO
;
Haibin SUN
- Keywords:
CD146;
TfR1;
epithelial ovarian cancer;
immunohistochemistry
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2017;38(1):104-107,135
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:Objective To evaluate the expressions of cell adhesion molecules CD146 and transferrin receptor 1 (TfR1)in ovarian epithelial cancer and investigate their relationship with clinical pathological features of patients with ovarian epithelial cancer (OEC ) so as to further explore the pathogenesis of OEC. Methods Immunohistochemistry was employed to determine the expressions of CD146 and TfR1 in normal,benign and ovarian cancer tissues.Results The immunohistochemical results showed that the positive expressions of CD146 and TfR1 gradually increased with the changes of normal,benign and malignant tissues in OEC.There were significant differences between all the groups (P<0.05).The advanced the clinical stage,the higher the expression rate (P<0 .0 5 ).The lower the histopathological differentiation,the higher the expression rate (P<0 .0 5 ).The expressions of CD146 and TfR1 were not correlated with age or pathological patterns (P>0.05).There was a significant correlation between expressions of CD146 and TfR1 in OEC (P<0.05,rs=0.532).Combined detection sensitivity and specificity were 82.4% and 75.0%.Conclusion The high expressions of CD146 and TfR1 may play a key role in the occurrance,progression and metastasis of OEC.They may be used as potential markers for diagnosis,postoperative follow-up and targeted therapy.
