Influence of PEG on heparin release of heparin-loading PCL/PEG vascular prosthesis membranes
10.3760/cma.j.issn.1673-4181.2016.06.007
- VernacularTitle:PEG对肝素化PCL/PEG人工血管膜材料中肝素释放的影响
- Author:
Ying MAO
;
Chaojing LI
;
Fujun WANG
;
Wen DING
;
Xingyan MI
;
Lu WANG
- Keywords:
Heparinization;
Blending;
Sustained release;
Vascular membrane material
- From:
International Journal of Biomedical Engineering
2016;39(6):350-353,361,后插3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of polyethylene glycol (PEG) on heparin release of heparinloaded polycaprolactone/polyethylene glycol (PCL/PEG) membranes used in artificial vascular peosthesis.Methods Heparin-loaded PCL/PEG membrane samples with different PEG mass contents of 0,0.5％,10％ and 15％ were prepared by blending method and freeze-drying technology.The influence of PEG on heparin release was experimental studied in vitro.The influence of PEG on the structural characteristics of the samples were investigated by X-ray diffraction,Fourier transform infrared spectrum and differential scanning calorimeter.Results The addition of PEG reduced the heparin release resistance.The results showed that the average release rate of heparin in the first day and the release amount for 34 d were improved.Both these parameters increased with the increase of PEG mass content.The X-ray diffraction,Fourier transform infrared spectroscopy and differential scanning calorimetry showed that the crystallinity of PCL membrane was slightly enhanced by the addition of heparin,but the overall effect was not significant.In addition,the addition of heparin could promote the crystalline grain growth of PEG,and a common distribution of heparin and PEG in the matrix was observed.Conclusions The heparin release control can be achieved by adjusting the PEG mass content in heparin-loading PCL/PEG membranes prepared by blending method and freeze-drying technology.The proposed samples may have anticoagulant effect,which can be expected to be used as small-diameter artificial vascular prosthesis material.
