Progress of the prevention and treatment of growth retardation in children with nephrotic syndrome
10.3760/cma.j.issn.1673-4408.2017.01.006
- VernacularTitle:儿童肾病综合征相关生长迟缓及防治进展
- Author:
Miao ZHANG
- Keywords:
Nephrotic Syndrome;
Children;
Growth Retardation
- From:
International Journal of Pediatrics
2017;44(1):24-27,31
- CountryChina
- Language:Chinese
-
Abstract:
Nephrotic syndrome(NS) is a common disease in children.Glucocorticoids(GC) is the firstline treatment for NS and can cause growth hormone(GH) secretion and synthesis disorder through various ways which reduces levels of GH.Consequently,the growth and development are affected.For another,kddney disease can intervene in the secretion and regulation of insulin-like growth factor (IGF) and insulin-like growth factor binding protein(IGFBP).GH-IGF axis's change plays a role in children's growth retardation.Other factors,such as bone metabolic disturbance and hypothyroidism aggravates the growth inhibition.This review focuses on the prevention and treatment of growth retardation in children with NS.
