Application of Matrix-assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry(MALDI-TOF MS) in the Laboratory Diagnosis of Filamentous Fungi
10.3969/j.issn.1671-7414.2017.01.002
- VernacularTitle:基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）分析在丝状真菌实验诊断中的应用
- Author:
Longrong ZHOU
;
Yuanhong XU
- Keywords:
matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS);
filamentous fungi
- From:
Journal of Modern Laboratory Medicine
2017;32(1):5-8,105
- CountryChina
- Language:Chinese
-
Abstract:
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)is a powerful tool for routine identification of a variety of microorganisms,including bacteria,yeast and filamentous fungi.Fast,accurate, high-throughput and low-cost characteristics,and gradually used for filamentous fungal infection in the laboratory diagnosis. In the MALDI-TOF MS analysis of filamentous fungi,from sample preparation to obtaining accurate identification results, each step determines whether the medical technician can provide accurate results for the clinician.This review will provide a systematic overview of the applications and prospects of filamentous fungal analysis (including identification,typing,and an-tifungal susceptibility testing)from preparation of the test sample to the MALDI-TOF MS technique,as well as a review of some of its future developments.
