Congenital Nephrogenic Diabetes Insipidus with Bilateal Hydronephrosis: Indomethacin in Treatment of Nephrogenic Diabetes Insipidus.
10.3349/ymj.1980.21.2.116
- Author:
Young Mo SOHN
1
;
Chul LEE
;
Pyung Kil KIM
;
Duk Jin YUN
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- MeSH:
Adolescent;
Bladder, Neurogenic/etiology;
Chlorothiazide/therapeutic use;
Diabetes Insipidus/complications;
Diabetes Insipidus/congenital*;
Diabetes Insipidus/drug therapy;
Diabetes Insipidus/genetics;
Drug Therapy, Combination;
Human;
Hydronephrosis/etiology*;
Indomethacin/therapeutic use*;
Male
- From:Yonsei Medical Journal
1980;21(2):116-122
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 13-year-old boy was diagnosed as having primary nephrogenic diabetes insipidus, and symptoms developed at 3 years of age. Subsequently he developed bilateral hydronephrosis and a neurogenic bladder. His pedigree could be explored back 5 generations and represented an inheritance as an X-linked recessive transmission factor. He was treated with indomethacin 2 mg/kg/day plus chlorothiazide 500 mg/day and this new treatment showed a markedly decreased urine output and increased urine osmolarity. (Nephrogenic diabetes insipidus, Hydronephrosis, Indomethacin)
