Type Ⅲ TGF-βreceptor mediated signaling pathway and its role in fibrotic diseases
10.3969/j.issn.1001-1978.2016.12.001
- VernacularTitle:TGF-βⅢ型受体介导的信号通路及其在纤维化疾病中的作用
- Author:
Xinran LI
;
Wuyi SUN
;
Yuanjing GU
;
Wenting PENG
;
Wei WEI
- Keywords:
type Ⅲ TGF-βreceptor;
fibrotic diseases;
signa-ling pathway;
β-arrestin2;
Smad;
MAPK
- From:
Chinese Pharmacological Bulletin
2016;32(12):1629-1633,1634
- CountryChina
- Language:Chinese
-
Abstract:
Transforming growth factor β(TGF-β)superfamily ligands play an important role in regulating cellular homeostasis including proliferation,differentiation,apoptosis,immune sur-veillance and angiogenesis.Type Ⅲ TGF-βreceptor (TβRⅢ) is considered to be the coreceptor of TGF-βsuperfamily.TβRⅢnot only has an effect on classical Smad signaling pathway,but also on non-Smad signaling pathway.TβRⅢplays a crucial role in fibrosis,tumor,cardiovascular diseases via mediating kinds of signaling pathways.This paper reviews TβRⅢ mediated sig-naling pathway and its role in fibrotic diseases.
