Research progress on pharmacogenetics in multidrug and toxin extrusion proteins
10.3969/j.issn.1001-1978.2016.12.003
- VernacularTitle:多药及毒素外排转运蛋白遗传药理学研究进展
- Author:
Zongping XIONG
;
Peng ZHU
;
Shiqiong HUANG
;
Qing LI
- Keywords:
multidrug and toxin extrusion proteins;
SNP;
met-formin;
cisplatin;
diabetes;
side efect
- From:
Chinese Pharmacological Bulletin
2016;32(12):1639-1642,1643
- CountryChina
- Language:Chinese
-
Abstract:
The body is equipped with kinds of transporters which generally exist in liver,kidney,and intestine.Multidrug and toxin extrusion proteins(MATEs;SLC47A)are predominantly expressed in the brush-border membrane of proximal tubule epi-thelial cells in the kidney and the canalicular membrane of hepa-tocytes.Functionally,MATEs act as efflux transporters for or-ganic compounds.The article discusses type,structure,poly-morphism and function of MATE1and MATE2-K,and also dis-cusses the effect of single nucleotide polymorphisms (SNPs)in the SLC47A1 gene and SLC47A2 on the pharmacokinetics and pharmacodynamics of metformin and platinum-based chemothera-peutic agents.
