Inhibition effect of bisoprolol combined with trimetazidine on myocardial remodeling in hypertensive myocardial hypertrophy
10.3969/j.issn.1005-1678.2016.11.013
- VernacularTitle:比索洛尔与曲美他嗪联用对高血压心肌肥厚患者心肌重构的抑制作用
- Author:
Cheng ZHANG
;
Bin GAO
- Keywords:
bisoprolol;
trimetazidine;
combination;
hypertension;
myocardial hypertrophy;
myocardial remodeling
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(11):50-52,55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the myocardial remodeling inhibition effect of bisoprolol combined with trimetazidine in the treatment of hypertensive myocardial hypertrophy.Methods 86 cases with hypertension and cardiac hypertrophy in Lingwu People’s Hospital of Ningxia from June 2015 to June 2016 were selected and randomly divided into two groups,43 cases in the control group received routine clinical treatment,43 cases in the experiment group received more with bisoprolol combined with trimetazidine treatment.Blood pressure,ultrasonic cardiogram,levels of serum TNF-α, MMP3 and CRP were compared before and after the treatment.Results Compared with before treatment,levels of blood pressure,IVST,LVPWT,LVMI, MMP3,TNF-αand serum CRP significantly decreased after treatment,and compared with the control group,levels of blood pressure,IVST,LVPWT, LVMI,MMP3,TNF-αand serum CRP in the experiment group were lower,the differences were statistically significant (P<0.05),and the effective rate in the experiment group was higher than the control group ( P<0.05 ) .Conclusion Bisoprolol combined with trimetazidine can effectively inhibit the remodeling of hypertension in patients with myocardial hypertrophy,has good clinical efficacy.
