Influence of ulinastatin on gastrointestinal function and inflammatory stress state in severe acute pancreatitis
10.3969/j.issn.1005-1678.2016.11.015
- VernacularTitle:乌司他丁对重症急性胰腺炎患者胃肠功能及炎性应激状态的影响
- Author:
Ning LIU
;
Guoxing DAI
- Keywords:
ulinastatin;
severe acute pancreatitis;
gastrointestinal function;
inflammatory stress state
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(11):56-58,61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of ulinastatin for the gastrointestinal function and inflammatory stress state of patients with severe acute pancreatitis.Methods 46 patients with severe acute pancreatitis in our hospital from October 2015 to July 2016 were randomly divided into control group and observation group with 23 cases in each group, the control group was treated with routine treatment of severe acute pancreatitis , the observation group was treated with ulinastatin on the basic treatment of control group, then the serum gastrointestinal hormones before and after meal and inflammatory stress indexes of two groups at different time before and after the treatment were compared .Results The serum gastrointestinal hormones before and after meal and inflammatory stress indexes of two groups before the treatment were compared,the differences were not significant,while the serum gastrointestinal hormones and inflammatory stress indexes of observation group after the treatment were all better than those of control group,the differences were all significant(all P<0.05).Conclusion The ulinastatin can significantly improve the gastrointestinal function and inflammatory stress state of patients with severe acute pancreatitis, so the application value in the patients with severe acute pancreatitis is higher.
