Effects of rosuvastatin on vascular endothelial function and inflammatory factors in acute myocardial infarction after PCI
10.3969/j.issn.1005-1678.2016.11.037
- VernacularTitle:瑞舒伐他汀对急性心肌梗死患者PCI术后血管内皮功能和炎性因子水平的影响
- Author:
Hui ZHANG
;
Qian WANG
- Keywords:
rosuvastatin;
acute myocardial infarction;
percutaneous coronary intervention;
thrombosis;
vascular endothelial function
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(11):124-126,130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of rosuvastatin on vascular endothelial function and inflammatory factors in patients with acute myocardial infarction ( AMI) after PCI.Methods A total of 217 patients from May 2014 to May 2016 in The Second Hospital of Baoding were randomly divided into the observation group 109 cases and the control group 108 cases.Two groups were treated with conventional basic therapy,and the control group was treated with atorvastatin,while the observation group was treated with rosuvastatin.The clinical efficacy,the levels of FMD and NMD,vascular endothelial function and inflammatory factors were compared between the two groups,and adverse reactions were recorded.Results The effective rate of the observation group was 95.41%,significantly higher than that of 86.11% in the control group (P<0.05);the levels of FMD and NMD in the two groups were significantly higher than before treatment,and the observation group was higher than the control group(P <0.05);the level of ET-1 was significantly decreased,and the levels of NO and NOS were significantly higher in the two groups,and the changes in the observation group were more significant(P<0.05);the levels of hs-CRP,TNF-α,IL-8,IL-6 was significantly decreased,the observation group was significantly lower than the control group( P <0.05 );and no serious adverse reactions were observed.Conclusion Rosuvastatin can improve the vascular endothelial function and inflammatory factor level of AMI patients after PCI,improve the curative effect and improve the quality of life of patients.
