Expression of HER-2 in colorectal cancer tissue and its correlation with vascular endothelial growth factor A
10.3760/cma.j.issn.1008-6706.2017.03.026
- VernacularTitle:人表皮生长因子受体2在结直肠肿瘤组织中的表达及其与血管内皮生长因子A的相关性
- Author:
Shucheng LIU
- Keywords:
Colorectal neoplasms;
Human epidermal growth factor receptor 2;
Vascular endothelial growth factor A;
Microvessel density
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(3):424-426,427
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of human epidermal receptor 2 (HER-2 ) expression in colorectal carcinoma.Methods Immunohistochemistry was used to detect HER-2 protein expression in 80 cases with colorectal carcinoma(colorectal cancer group)and 30 cases of normal colon tissues adjacent to tumor tissue>5 cm (control group).Results The positive rate of HER-2 in colorectal carcinoma group was 6 1 .25%, which in control group was 3.33%.The positive rate of VEGF-A in colorectal carcinoma group was 65.00%,which in control group was 3.33%.The expression of HER-2 and VEGF-A in colorectal cancer tissues was correlated with tumor differentiation,lymph node metastasis and clinical classification (P<0.05 ),which was independent of gender and tumor size (P>0.05 ).Pearman grade correlation analysis showed that the expression of HER-2 was positively correlated with the expression of VEGF-A in colorectal cancer tissues (r=0.736,P<0.05).The positive expression of HER-2 was (61.5 ±9.4),and the MVD value of the control group was (7.8 ±48.3),and there was significant difference between the two groups(t=8.440,P<0.01 ).Conclusion The expression of HER-2 plays an important role in the invasion and metastasis of colorectal cancer,colorectal cancer with high expression of HER-2 maybe through promoting VEGF-A expression in vivo and increasing vascular density in patients,thus to speed up the development and progression of colorectal cancer.
