Effect of amino acid receptor antagonists in the treatment of vascular dementia after cerebral apoplexy in elder in the function of study and memory
10.3969/j.issn.1005-1678.2016.11.052
- VernacularTitle:氨基酸受体拮抗剂对老年脑卒中后引发血管性痴呆患者学习记忆的影响
- Author:
Honghui WEI
;
Minjun WEI
- Keywords:
amino acid receptor antagonist;
elderly;
stroke;
vascular dementia;
learning and memory
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(11):173-175,178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of amino acid receptor antagonists in the treatment of vascular dementia after cerebral apoplexy in elder in the function of study and memory.Methods 68 elder patients(≥65 years older) with vascular dementia caused by stroke from August 2014 to December 2015 in tongde hospital of zhejiang province were selected and randomly divided into study group and control group , 34 cases in each group.The control group received the convention treatment and combined with compound haishe capsule three pills each time , three times/day,the study group received convention treatment and combined with memantine three weeks before 5-15 mg/day,fourth week 20 mg/day,two groups were treated for six months.Cerebrospinal fluid,hematological and clinical indexes were compared before and after treatment.Results Compared with before treatment, levels of SS and AVP of cerebrospinal fluid in two groups after treatment increased,levels of MMSE and HDS-R increased,scores of ADL decreased, levels of P300 in latency decreased and levels of P300 in amplitude increased,levels of VEGF and BDNF increased,the differences were statistically significant (P<0.05).Compared with the control group,levels of SS and AVP in cerebrospinal fluid in the study group were higher,levels of MMSE and HDS-R were higher,scores of ADL were lower,levels of P300 in latency were lower and levels of P300 in amplitude were higher,and levels of VEGF and BDNF were higher,the differences were statistically significant (P<0.05).Conclusion Amino acid receptor antagonists can increase the ability of learning and memory in patients with senile vascular dementia after stroke, and it can improve the cerebrospinal fluid and blood indexes.
