Effect of nerve invasion on long term survival of middle and distal cholangiocarcinoma
10.3760/cma.j.issn.1673-4203.2017.01.007
- VernacularTitle:神经浸润对肝外中远端胆管癌长期生存的影响
- Author:
Peng LI
;
Hao GUO
;
Lanbin LI
;
Yan LIU
- Keywords:
Bile duct neoplasms;
Nerve;
Invasion;
Prognosis
- From:
International Journal of Surgery
2017;44(1):23-26,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the long-term survival of patients with middle and distal cholangiocarcinoma,and to explore the influence of nerve invasion on the survival time.Methods We retrospectively analyzed the clinical data of 161 patients with middle or distal cholangiocarcinoma in General Hospital of Fushun Mining Bureau between January 2012 and June 2016.All the patients were divided into nerve group and control group according to the nerve invasion.And then the perioperative and prognosis data of the two groups were analyzed and compared.Results In our research,all patients were successfully completed surgery,the incidence of neural invasion was 47.2％ (76/161),more common of the nerve invasion in distal cholangiocarcinoma and phase Ⅱ cholangiocarcinoma.The perioperative mortality rate was 3.7％ (6/161),and the incidence of complications was 27.3％ (44/161).The 1 years,2 years and 3 years survival rates of middle and distal cholangiocarcinoma were 78.7％,42.1％,20.0％,the average survival time was(23.8 ±1.2) months.The 1 years,2 years and 3 years survival rates of nerve group and control group were 67.1％,29.8％,9.4％ and 89.0％,52.6％,26.8％,the average survival time were (18.6 ± 1.4) months and (27.3 ± 1.6) months.The prognosis of nerve group was significantly poor than the control group (P ＜ 0.05).Conclusions Nerve invasion is a common way of invasion and metastasis of cholangiocarcinoma.And it has a poor prognosis in cholangiocarcinoma patients with nerve invasion.
