C3 nephropathy in renal allograft
10.3760/cma.j.issn.1008-1372.2017.01.005
- VernacularTitle:移植肾C3肾病
- Author:
Jiqiu WEN
- Keywords:
Kidney transplantation;
Nephrosis;
Complement C3
- From:
Journal of Chinese Physician
2017;19(1):17-18,21
- CountryChina
- Language:Chinese
-
Abstract:
The term of C3 nephropathy was formally published in 2013,which was separated into C3 glomerulonephritis (C3GN) and dense deposit disease (DDD).C3 nephropathy was defined with special histological changes and special pathophysiological mechanism.C3 GN in renal allograft was reported in recent years.The diagnosis of C3 nephropathy in renal allograft was the same as in native kidneys.The phathophysiological mechanism of C3 nephropathy was related to the abnormal alternative complement pathway.C3GN recurs in 66.7％ of patients,and DDD recurs in over 80％ of patients.There was no effective therapy for C3 nephropathy.There was sporadic report that eculizumab was effective for C3 nephropathy,which should be further confirmed in the future.
