Umbilical cord blood pluripotent stem cell immune education treatment for juvenile type 1 diabetes

VernacularTitle:脐血多能干细胞免疫教育治疗青少年1型糖尿病
Author: Yani PENG ; Haibo YU ; Yong ZHAO ; Zhiguang ZHOU
Keywords: Fetal blood; Multipotent stem cells; Immunotherapy; Education; Diabetes mellitus,type 1/IM/TH
From: Journal of Chinese Physician 2017;19(1):4-6,13
CountryChina
Language:Chinese
Abstract: Type 1 diabetes is a autoimmune disease that occurs under the influence of both genetic predisposition and environmental factors,mediated mainly by T lymphocytes with various kinds of other involved immune cells.The autoimmune attacks eventually lead to the islet beta cell destruction and insulin insufficiency.Multiple fundamental studies and clinical trials have revealed that umbilical cord blood pluripotent stem cells have the potential to help restore immune balance,induce immune tolerance,stop the autoimmune attacks against beta cells,and promote beta cell regeneration in type 1 diabetes mellitus (T1DM),by means of cell to cell contact and soluble cytokine secretion.For the past few years,the National Clinical Research Center for Metabolic Diseases of Second Xiangya Hospital has been leading the research on stem cell education therapy and has performed the therapy for 35 juvenile type 1 diabetes patients from China and foreign countries,introducing a novel treatment for T1DM.