Clinical analysis of plasma cystatin-C levels in patients with primary hypertension and obstructive sleep apnea syndrome
10.3760/cma.j.issn.1008-1372.2016.12.009
- VernacularTitle:原发性高血压合并阻塞性睡眠呼吸暂停综合征患者血浆胱抑素C水平的临床分析
- Author:
Qian HE
;
Yanshan LIU
;
Guifang ZENG
;
Jie FENG
;
Yuqing ZHANG
;
Xiang PENG
;
Ying GUO
- Keywords:
Hypertension/CO/ME;
Sleep apnea,obstructive/CO/ME;
Cysteine proteinase inhibitors/ME
- From:
Journal of Chinese Physician
2016;18(12):1794-1796,1800
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of obstruction sleep apnea syndrome (OSAS) on plasma cystatin C (CC) levels in patients with primary hypertension.Methods A total of 244 cases of primary hypertension patients was chosen.The patients were divided into observation group (with OSAS) and control group (without OSAS) according to apnea hypopnea index (AHI).The observation group was then divided into three subgroups:mild OSAS group,moderate OSAS group,and severe OSAS group.The levels of CC were compared.Results First,the plasma CC levels in patients with primary hypertension had no statistical significance in the differences among different grades of hypertension (P ＞ 0.05).Second,CC levels of observation group were significantly higher than control group (P ＜ 0.05).Third,CC levels of the severe group were higher than the moderate group,and the plasma CC levels of the moderate group were also higher than the mild group and control group.Rank correlation analysis and comparison of CC levels and AHI showed that CC levels were positively correlated with AHI (r =0.585,P ＜ 0.01).However,there were no statistically significant differences between CC levels of the mild OSAS group and control group (P ＞ 0.05).Conclusions The patients with OSAS and primary hypertension had higher levels of CC,and aggravated with the progress of the degree of obstruction.CC may be involved in the progression of the disease,a high level of CC may aggravate the condition,it should be early prevention and treatment.
