Clinical Observation of High-dose Valaciclovir Combined with Acupuncture in the Treatment of Herpes Zoster ZHOU
10.6039/j.issn.1001-0408.2016.26.28
- VernacularTitle:大剂量伐昔洛韦联合针刺治疗带状疱疹的临床观察
- Author:
Jian LI
- Publication Type:Journal Article
- Keywords:
Acupuncture;
Valaciclovir;
High-dose;
Herpes zoster;
Clinical efficacy;
Postherpetic neuralgia
- From:
China Pharmacy
2016;27(26):3690-3691,3692
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical efficacy and safety of high-dose valaciclovir combined with acupuncture in the treatment of herpes zoster. METHODS:194 patients with herpes zoster were divided into control group and observation group according to random number table method,with 97 cases in each group. Control group was given acupuncture treatment;observa-tion group was additionally given Valaciclovir hydrochlordide tablet 0.3 g,bid,based on control group. Both group received treat-ment for 10 d. Clinical efficacy and the time of clinical symptoms improvement were observed in 2 groups as well as VAS score and substance P level before and after treatment. The occurrence of postherpetic neuralgia and ADR were also observed in 2 groups. RESULTS:Total effective rate of observation group was 97.9%,which was significantly higher than 90.7% of control group,with statistical significance(P<0.05). The analgesic time,stopping herpes time,lesion scabby time,lesion disappeared time of observa-tion group were significantly shorter than those of control group,with statistical significance(P<0.05). There was no statistical sig-nificance in VAS score and substance P level between 2 groups before treatment(P>0.05);those of 2 groups were decreased sig-nificantly after treatment,and the observation group was lower than the control group,with statistical significance(P<0.05). The incidence of postherpetic neuralgia in observation group was 14.4%,which was significantly lower than 28.9% of control group, with significant difference (P<0.05). There was no statistical significance in the incidence of ADR between 2 groups (P>0.05). CONCLUSIONS:High-dose valacyclovir combined with acupuncture can effectively treat herpes zoster,with advantages of analge-sic effect,rapid lesions recovery,low rate of postherpetic neuralgia with good safety.
