Clinical Observation of Cinobufacini Capsule in the Treatment of Intractable Hiccup
10.6039/j.issn.1001-0408.2016.24.11
- VernacularTitle:华蟾素胶囊治疗肿瘤患者顽固性呃逆的临床观察
- Author:
Liu YANG
- Publication Type:Journal Article
- Keywords:
Cinobufacini capsule;
Intractable hiccup;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(24):3348-3349,3350
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy and safety of Cinobufacini capsule in the treatment of tumor patients with intractable hiccup. METHODS:120 tumor patients with intractable hiccup were randomly divided into observation group(60 cases) and control group (60 cases) according to the random number table. Control group received conventional treatment,treat-ment of primary disease,and the basic treatment of Methoxy metoclopramide tablets 10 mg,tid and intraorbital pressure on neural network method;observation group additionally received Cinobufacini capsule,2 capsules once,3 times a day. 1-week was regard-ed as a treatment course,and it lasted 4 courses. Clinical efficacy,Karnofsky functional status(KPS)score and disappearance time of hiccup were observed,and the incidence of adverse reactions was evaluated by TESS scale. RESULTS:After treatment,the to-tal effective rate in observation group was significantly higher than control group,the disappearance time of hiccup and TESS score were significantly shorter than control group,the differences were statistically significant(P<0.05). Before treatment,there was no significant difference in the KPS score;after treatment,the KPS score in 2 groups was significant higher than before,and observa-tion group was higher than control group,the difference was statistically significant(P<0.05). CONCLUSIONS:Both efficacy and safety of Cinobufacini capsule in the treatment of intractable hiccup are good,and it can shorten hiccup duration.
