Comparison of Sedative Effect of Dexmedetomidine and Midazolam on Patients with Comprehensive ICU Me-chanical Ventilation
10.6039/j.issn.1001-0408.2016.24.09
- VernacularTitle:右美托咪定与咪达唑仑用于ICU机械通气患者的镇静效果比较
- Author:
Xiang WU
;
Fei TAO
;
Xiaodi WU
;
Xiaru LOU
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Midazolam;
ICU;
Mechanical ventilation;
Sedation
- From:
China Pharmacy
2016;27(24):3343-3344,3345
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the sedative effects of dexmedetomidine and midazolam in patients with comprehensive ICU mechanical ventilation. METHODS:74 patients in ICU were randomly divided into dexmedetomidine group (37 cases) and midazolam group (37 cases). Based on mechanical ventilation,dexmedetomidine group received 200 μg Dexmedetomidine injec-tion,dissolving in 48 ml 0.9% Sodium chloride injection,pumped by 1 μg/kg within 30 min,then adjusted to 0.2-0.7 μg/(kg·h) by micropump. Midazolam group received 30 mg Midazolam injection,dissolving in 44 ml 0.9% Sodium chloride injection, pumped by 0.05 mg/kg within 15 min,then adjusted to 0.04-0.20 mg/(kg·h)by micropump. The sedative effects,clinical indica-tors(weaning time,extubation time,time of mechanical ventilation,ICU hospitalization time)and the incidence of adverse reac-tions in 2 groups were observed. RESULTS:There was no significant difference in the sedative effects(P>0.05);weaning time, extubation time,and ICU hospitalization time in dexmedetomidine group were significantly shorter than midazolam group,the dif-ferences were statistically significant(P<0.05);the incidence of total adverse reactions in dexmedetomidine group was significant-ly lower than midazolam group,the difference was statistically significant (P<0.05). CONCLUSIONS:Dexmedetomidine show similar sedative effects with midazolam in patients with comprehensive ICU mechanical ventilation,shorter weaning time,extuba-tion time,ICU hospitalization time,and lower incidence of total adverse reactions than midazolam.
