Cost-minimization Analysis of Interferonα1b and Interferonα2b in the Treatment of Chronic Hepatitis C
10.6039/j.issn.1001-0408.2016.23.03
- VernacularTitle:干扰素α1b与α2b治疗慢性丙型肝炎的最小成本分析
- Author:
Mingming ZHANG
;
Fei LYU
;
Yidan XU
;
Li ZHENG
;
Xing YU
;
Yan LI
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
Interferonα1b;
Interferonα2b;
Chronic hepatitis C;
Pharmacoeconomics;
Cost-minimization analysis
- From:
China Pharmacy
2016;27(23):3175-3176,3177
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the economics of interferon α1b and α2b in the treatment of chronic hepatitis C. METH-ODS:By retrospective study,114 patients with chronic hepatitis C who received interferon were selected,60 patients received interfer-on α1b were divided into group A and 54 patients received interferon α2b were divided into group B. Negative conversion rate of HCV-RNA,normalization rate of ALT and the incidence of ADR in 2 groups were compared,and pharmacoeconomic analysis was conducted. RESULTS:Negative conversion rates of HCV-RNA in group A in 4,12,24,36,48 weeks were 55.00%,71.67%, 63.33%,61.67% and 65.00%,group B were 64.81%,66.67%,62.96%,55.56% and 61.11%,respectively,there were no signifi-cant differences between 2 groups (P>0.05);after treatment,normalization rate of ALT in group A was 95.23%,group B was 96.10%,there was no significant difference between 2 groups(P>0.05);and there were no significant differences in the incidence of ADR between 2 groups (P>0.05),so cost-minimization analysis was used to evaluate pharmacoeconomics. Therapy cost in group A was 13 216.56 yuan,group B was 7 929.60 yuan,group B was lower to group A;sensitivity analysis received the same results. CON-CLUSIONS:Interferonα2b is more economical thanα1b in the treatment of chronic hepatitis C.
