Clinical Observation of Leflunomide Combined with Prednison in the Treatment of Membranous Nephropathy
10.6039/j.issn.1001-0408.2016.23.19
- VernacularTitle:来氟米特联合泼尼松治疗膜性肾病的临床观察
- Author:
Yali MA
;
Fang CHEN
;
Jun SHI
;
Baoping CHEN
- Publication Type:Journal Article
- Keywords:
Membranous nephropathy;
Leflunomide;
Prednison;
Renal function;
Serum lipid;
Clinical efficacy
- From:
China Pharmacy
2016;27(23):3224-3225,3226
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the efficacy and safety of leflunomide combined with prednison in the treatment of membra-nous nephropathy. METHODS:43 patients with primary membranous nephropathy were randomly divided into control group(21 cas-es) and test group (22 cases). Control group given cyclophosphamide interrupted shocks combined with prednison,test group re-ceived leflunomide combined with prednison,the treatment course for both groups was 12 months. 6 months after the treatment,clini-cal efficacy,changes in renal function and serum lipids indexes before and after treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in test group was 63.64%,which was significantly higher than control group (23.81%),the difference was statistically significant (P<0.05). After treatment,urine protein in 2 groups significantly de-creased,plasma albumin significantly increased,serum creatinine,serum cholesterol,triglycerides and low-density lipoprotein signifi-cantly decreased,the differences were statistically significant(P<0.05);and the changes of above-mentioned indexes(except blood cholesterol)in test group were more significantly than control group,the differences were statistically significant(P<0.05). The inci-dence of adverse reactions in test group was 9.09%,control group was 9.52%,there was no significant difference between 2 groups (P>0.05). CONCLUSIONS:Compared with cyclophosphamide interrupted shocks combined with prednison,the efficacy of lefluno-mide combined with prednison in the treatment of membranous nephropathy is more definite,and the improvement of renal function and serum lipids indexes is more obvious.
