Monitoring of Plasma Concentration and Analysis of Influential Factors for Paliperidone Palmitate Injection in 37 Patients with Schizophrenia
10.6039/j.issn.1001-0408.2016.23.10
- VernacularTitle:37例精神分裂症患者棕榈酸帕利哌酮注射液血药浓度监测及其影响因素分析Δ
- Author:
Kankan QU
;
Zhenxian SHEN
;
Zhongdong ZHANG
- Publication Type:Journal Article
- Keywords:
Paliperidone palmitate injection;
Plasma concentration;
Gender;
Age;
Daily dosage;
Drug combination;
Schizo-phrenia
- From:
China Pharmacy
2016;27(23):3197-3199,3200
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the influential factors for plasma concentration of paliperidone palmitate injection for pa-tients with schizophrenia. METHODS:37 schizophrenia patients who used Paliperidone palmitate injection and took plasma concentra-tion monitoring in Wuxi Mental Health Center from Sept. 2012 to Jun. 2015 was selected,the results were statistically analyzed,and the influential factors were preliminary explored. RESULTS:Totally 37 times were conducted for the plasma concentration monitoring for paliperidone with the average plasma concentration of(17.72±13.46)ng/ml,and 24 times(accounting for 64.86%)in the range of(10-60 ng/ml);the average plasma concentration of male patients was lower than that of female patients,the difference was statisti-cally significant(P<0.05);there was no significant difference in the average plasma concentration among different ages(P>0.05);there was also no significant difference in plasma concentration/dose ratio in patients with different daily dose(P>0.05);the average plasma concentration of patients with combination treatment was higher than that of single drug,the difference was statistically signifi-cant(P<0.05);and there was no significant difference in the average plasma concentration of relieved patients and ineffective treat-ment patients(P>0.05). CONCLUSIONS:The plasma concentration of paliperidone palmitate is affected by age,combination treat-ment and other factors,clinic can optimize the therapeutic regimen based on monitoring results of plasma concentration and patients’ symptoms to promote the rational drug use.
