Expression Pattern of Immunoproteasome Subunits in Human Thymus.
- Author:
Kwon Ik OH
1
;
Jae Nam SEO
Author Information
- Publication Type:Brief Communication
- Keywords: Immunoproteasome; MHC (major histocompatibility complex); Peptide; Selection
- MeSH: Adult; Humans; Immunohistochemistry; Stromal Cells; Thymus Gland
- From:Immune Network 2009;9(6):285-288
- CountryRepublic of Korea
- Language:English
- Abstract: The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes.
