Relationship of plasma levels of natriuretic peptide and high sensitivity C-reactive protein in the patients with different phenotypes of coronary heart desease
10.3969/j.issn.1673-4130.2016.18.009
- VernacularTitle:脑钠肽及超敏C反应蛋白水平与不同类型冠心病的关系
- Author:
Lisha NIE
;
Yongping MU
- Publication Type:Journal Article
- Keywords:
CHD;
NT-proBNP;
hs-CRP
- From:
International Journal of Laboratory Medicine
2016;37(18):2529-2530,2533
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observed the changes of plasma levels of NT‐proBNP and hs‐CRP in patients with different types of coronary heart disease and investigate its clinical value .Methods 156 patients with CHD diagnosed by coronary computed tomo‐graphy angiography(CTA) were enrolled in this study ,including 35 cases of acute myocardial infarction(AMI) ,63 cases of unstable angina(UAP) and 58 cases of stable angina(SAP) .And 61 persons without CHD were selected as the control(CTR) .Plasma levels of NT‐proBNP and hs‐CRP were detected by the methods of immmunofluorescent antibody technic reader and turbidimetry ,respec‐tively .Results Plasma NT‐proBNP levels of AMI ,UAP ,SAP and CTR group were (1 903 .99 ± 2 055 .21) ,(897 .27 ± 947 .34) , (677 .98 ± 718 .12) ,(129 .39 ± 126 .49)ng/L ,respect ively .Plasma hs‐CRP levels were (28 .47 ± 20 .49) ,(12 .68 ± 8 .64) ,(10 .56 ± 7 .17) ,(2 .82 ± 1 .23)mg/L ,respectively .Plasma levels of NT‐proBNP and hs‐CRP in AMI group were obviously higher than those in UAP ,SAP and CTR group(P<0 .05) .Plasma levels of NT‐proBNP and hs‐CRP in UAP group were obviously higher than those in CTR group(P<0 .05) .There was no significant differences in these markers between SAP group and control group(P>0 .05) . Plasma BNP levels were positively correlated with plasma hs‐CRP .Conclusion Plasma levels of NT‐proBNP and hs‐CRP are asso‐ciated with different clinical phenotyes of CHD .Those markers may be helpful to the risk stratification and prognosis of CHD .
