Effects of Single Administration by Different Ways on Drug Accumulation Concentration and Treatment of Tumor Tissue before Surgery
10.6039/j.issn.1001-0408.2016.21.11
- VernacularTitle:术前卡铂不同途径单次给药对肿瘤组织药物聚集浓度与化疗效果的影响
- Author:
Xiao XIE
- Publication Type:Journal Article
- Keywords:
Carboplatin;
Intraperitoneal injection;
Intravenous infusion;
Tumor tissue;
Drug accumulation concentration
- From:
China Pharmacy
2016;27(21):2913-2914,2915
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of single administration of carboplatin by different ways on drug accumulation concentration and treatment of tumor tissue before surgery. METHODS:60 patients with resectable advanced gastric cancer were randomly divided into intraperitoneal administration group(30 cases)and intravenous administration group(30 cases). All patients received 50 mg/m2 Carboplatin injection,intravenous administration,it stopped 4 weeks after continuous 5 d,repeated 3 times, when the last chemotherapy,intraperitoneal administration group was given 30 mg/m2 Carboplatin injection,adding into 750 ml 0.9% Sodium chloride injection,and placed in 37 ℃ water bath for preheating,taking paracentesis for disposable rapid injection. Intravenous administration group was 30 mg/m2 Carboplatin injection,adding into 750 ml 0.9%Sodium chloride injection,by intra-venous infusion within 30 min. Both groups were administered once for at least 1 week,then surgery was taken after 5 d. The car-boplatin accumulation concentration in 2 groups was determined after 160-180 min and 250-260 min,respectively,and the efficacy in the 5th day and incidence of adverse reactions during treatment were recorded. RESULTS:The total effective rate after 5 d,peri-toneal fluid,portal vein and peripheral blood after 160-180 min,and carboplatin accumulation concentration in cancer tissues,adja-cent normal tissues,peritoneum,omentum and negative lymph node after 250-260 min in intraperitoneal administration group were significantly higher than intravenous administration group,the incidence of adverse reactions was significantly lower than intrave-nous administration group,the differences were statistically significant(P<0.05). CONCLUSIONS:Compared with intravenous in-fusion,intraperitoneal injection of carboplatin before surgery can improve the local accumulation concentration and chemotherapeu-tic effect and reduce incidence of adverse reactions.
