Effectiveness and Safety of Methotrexate in the Treatment of Rheumatoid Arthritis:A Systematic Review
10.6039/j.issn.1001-0408.2016.21.17
- VernacularTitle:甲氨蝶呤治疗类风湿关节炎有效性与安全性的系统评价
- Author:
Ying LAN
;
Die HU
;
Haining SONG
;
Shijing HUANG
;
Qin HE
- Publication Type:Journal Article
- Keywords:
Methotrexate;
Rheumatoid arthritis;
Effectiveness;
Safety;
Systematic review
- From:
China Pharmacy
2016;27(21):2928-2932,2933
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the effectiveness and safety of methotrexate(MTX)in the treatment of rheuma-toid arthritis,and provide evidence-based reference for clinical treatment. METHODS:Retrieved from Medline,EMBase,Cochrane Library,PubMed,CJFD,CBM,VIP and Wanfang Database,randomized controlled trials(RCT)about MTX in the treatment of rheu-matoid arthritis were collected,Meta-analysis was performed after data extraction and quality evaluation. RESULTS & CONCLU-SIONS:33 effectiveness evaluation were included,involving 8 253 patients,and 53 safety evaluation were included,involving 4 803 patients. Results of analysis show,the efficacy of MTX was not higher than leflunomide in the treatment of rheumatoid arthritis,superi-or to cyclosporine A,and similar to sulfasalazine. In addition,MTX shows similar efficacy with etanercept(7.5-20 mg per week),goli-mumab,adalimumab or rituximab,but less effective than trastuzumab. The incidence of adverse reactions of MTX is high,but mainly mild or moderate,and the most common adverse reactions are gastrointestinal symptoms. Oral administration of MTX is more secure than intramuscular injection and subcutaneous injection.
