Clinical Observation of Methotrexate,Mifepristone Combined with Huayu Xiaozheng Decoction in the Treat-ment of Uterine Scar Pregnancy
10.6039/j.issn.1001-0408.2016.21.14
- VernacularTitle:甲氨蝶呤、米非司酮联合化瘀消癥汤治疗子宫瘢痕妊娠的临床观察
- Author:
Yuexiang PENG
;
Min HUANG
;
Hui CAO
;
Yuanyuan ZHANG
;
Jing WANG
;
Xiaoxin YANG
- Publication Type:Journal Article
- Keywords:
Methotrexate;
Mifepristone;
Huayu xiaozheng decoction;
Uterine scar pregnancy;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(21):2921-2922,2923
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the efficacy and safety of methotrexate (MTX),Mifepristone combined with Huayu xiaozheng decoction in the treatment of uterine scar pregnancy. METHODS:86 patients with uterine scar pregnancy were randomly divided into control group(43 cases)and observation group(43 cases). Control group orally received 50 mg ultrasound-guided lo-cal injections of MTX,once a day+50 mg Mifepristone tablet,twice a day;observation group additionally received 100 ml Huayu xiaozheng decoction,twice a day with warm temperature. The treatment course for both groups was 15 d. Clinical efficacy,HCG levels,mass diameter before and after 7,14 and 28 d of treatment,and the incidence of adverse reactions in 2 groups were ob-served. RESULTS:The total effective rate in observation group was significantly higher than control group,the difference was sta-tistically significant(P<0.05). HCG levels and mass diameter after 7,14 and 28 d were significantly lower than before,it gradual-ly reduced by time prolonged,and research group was lower than control group,the differences were statistically significant(P<0.05 or P<0.01). And there was no significant difference in the incidence of adverse reactions(P>0.05). CONCLUSIONS:Ultra-sound-guided local injections of MTX combined with Huayu xiaozheng decoction shows good efficacy and safety in the treatment of uterine scar pregnancy.
