Rapid Contents Determination of Potassium Chloride and Calcium Chloride in Compound Sodium Chloride Injection by ICP-OES
10.6039/j.issn.1001-0408.2016.18.30
- VernacularTitle:ICP-OES法快速测定复方氯化钠注射液中氯化钾和氯化钙的含量
- Author:
Weiming ZHOU
;
Huajin LI
;
Guohua CHENG
- Publication Type:Journal Article
- Keywords:
ICP-OES;
Compound sodium chloride injection;
Potassium chloride;
Calcium chloride;
Content determination
- From:
China Pharmacy
2016;27(18):2538-2539,2540
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for the rapid contents determination of potassium chloride and calcium chloride in Compound sodium chloride injection. METHODS:After diluted in appropriate way,Compound sodium chloride injection was sampled directly and contents of potassium chloride and calcium chloride were determined simultaneously by ICP-OES. The powder was 1 300 W,plasma gas flow rate was 15 L/min,auxiliary cooling gas flow was 0.2 L/min,atomizer flow rate was 0.8 L/min, the peristaltic pump rate was 0.8 L/min,atomizer pressure was 315 kPa,and the observation was axial observation,analysis spec-tral lines of potassium and calcium were 766.490 nm and 315.887 nm. RESULTS:The linear ranges of potassium and calcium were 1.0-12.0 mg/L (r=0.999 7 and 0.999 9);RSDs of precision and reproducibility tests were lower than 1%;recoveries were 98.5%-100.5%(RSD=0.59%,n=9)and 99.3%-102.3%(RSD=0.98%,n=9). CONCLUSIONS:The method is simple,rapid and simple,and can be used for the quality control of Compound sodium chloride injection.
