Clinical Observation of Budesonide,Azithromycin Combined Terbutaline in the Treatment of Infantile Acute Bronchitis
10.6039/j.issn.1001-0408.2016.18.24
- VernacularTitle:布地奈德、阿奇霉素联合特布他林治疗小儿急性支气管炎的临床观察
- Author:
Bei ZHAO
;
Renjie TONG
;
Chunfen ZHANG
;
Ying ZHANG
- Publication Type:Journal Article
- Keywords:
Terbutaline;
Budesonide;
Azithromycin;
Pediatric acute bronchitis;
Lung function;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(18):2519-2520,2521
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficiency and safety of budesonide,azithromycin combined with terbutaline in the treatment of infantile acute bronchitis. METHODS:150 children with acute bronchitis were randomly divided into control group(75 cases) and observation group(75 cases). All children were given electrolyte supplement,antiasthmatic,antispasmodic and other conventional treatment;based on it,control group was treated with 10 mg/kg Azithromycin injection,adding into 250 ml 5% Glu-cose injection,by intravenous infusion with time of more than 60 min,once everyday+2 mg Terbutaline sulfate spray solution,add-ing into 2 ml 0.9%sodium chloride injection,aerosal inhalation,twice a day,15 min for every times. Observation group was addi-tionally given 1.0 mg Budesonide aerosol;3 times a day,10 min for every times. The treatment course for both groups was 10 d. FEV1,MEF50,PEF before and after treatment,total effective rate and disappearance time of clinical symptoms,hospitalization time and incidence of adverse reactions were recorded. RESULTS:The total effective rate in observation group were significantly higher than control group,disappearance time of clinical symptoms and hospitalization time were significantly shorter than control group,the differences were statistically significant(P<0.05). After treatment,FEV1,MEF50 and PEF in 2 groups were significant-ly higher than before,and observation group was higher than control group,the differences were statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Based on conventional treament,budesonide,azithromycin combined with terbutaline is effective in the treatment of infantile acute bronchi-tis,and it can significantly improve lung function,with good safety.
