Effects of Shengmai Injection on Myocardial Function of Patients with General Anesthesia of Hysterectomy
10.6039/j.issn.1001-0408.2016.17.36
- VernacularTitle:生脉注射液对子宫切除术全身麻醉患者心肌功能的影响
- Author:
Yuling HAO
;
Qiyun SHEN
- Publication Type:Journal Article
- Keywords:
Shengmai injection;
Myocardial function;
Hysterectomy;
General anesthesia
- From:
China Pharmacy
2016;27(17):2410-2411,2412
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect and safety of Shengmai injection on myocardial function of patients with gen-eral anesthesia of hysterectomy. METHODS:40 patients underwent hysterectomy were randomly divided into observation group and control group with 20 cases in each group. Both groups received general anesthesia induction of fentanyl citrate and rocuroni-um,and inhalation anesthesia of propofol. Observation group was given Shengmai injection 1 ml/kg,ivgtt;control group was given same dose of 0.9%Sodium chloride injection,ivgtt,before anesthesia. Mean arterial pressure(MAP),heart rate(HR),central ve-nous pressure(CVP),blood oxygen saturation(SpO2),the levels of MDA,SOD and NOS were compared between 2 groups be-fore operation(T0),before anesthesia induction(T1),reaction during(T2),after operation(T3). The occurrence of ADR was also observed. RESULTS:There was no statistical significance in MAP and HR between 2 groups at T0 and T1 (P>0.05). MAP and HR of observation group was significantly higher than those of control group at T2 and T3,with statistical significance(P<0.05). There was no statistical significance in CVP and SpO2 between 2 groups at different time points(P>0.05). There was no statistical significance in MDA,SOD and NOS levels between 2 groups at T0(P>0.05). MDA and NOS levels of 2 groups increased signifi-cantly at T1,T2 and T3,while SOD level decreased significantly;MDA and NOS level of observation group were lower than the control group while SOD level was higher than control group at T1,T2,with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Shengmai injection can maintain stable HR and MAP,and reduce the oxide in patients underwent hysterectomy surgery so as to protect myocardial function with good safety.
