Clinical Observation of Citalopram in the Treatment of Depression after Lung Cancer Operation
10.6039/j.issn.1001-0408.2016.17.38
- VernacularTitle:西酞普兰治疗肺癌术后抑郁症的临床观察
- Author:
Zhenqing SUN
;
Qiang GUO
;
Hefei LI
;
Haibo WANG
;
Jinchi ZU
;
Lin SHI
;
Yue ZHANG
;
Yajing LI
;
Wenhua SANG
- Publication Type:Journal Article
- Keywords:
Citalopram;
Depression;
Safety;
Lung cancer
- From:
China Pharmacy
2016;27(17):2415-2416,2417
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe clinical efficacy and safety of citalopram in the treatment of depression patients after lung cancer operation. METHODS:114 depression patients after lung cancer operation were selected and randomly divided into observa-tion group and control group (n=57). Control group was given routine treatment as nutrition support and electrolyte balance,but had no anti-depression drugs;observation group was given Citalopram tablet 20 mg orally,qd. Two groups were treated for 6 weeks. Clinical efficacy,HAMD and HAMA scores,each score and total score of SF-36 were observed before and after treatment. The occurrence of ADR was recorded. RESULTS:The total effective rate of observation group was 87.72%,which was significant-ly higher than that that of control group(71.93%),with statistical significance(P<0.05);there was no statistical significance in HAMA score,HAMD score,each score and total score of SF-36 between 2 groups before treatment(P>0.05);HAMA score and HAMD score of 2 groups decreased significantly after treatment,the observation group was lower than the control group;each score and total score of SF-36 increased significantly,the observation group was higher than the control group,with statistical sig-nificance(P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Citalopram is effective and safe for depression af-ter lung cancer operation,can improve mental state and quality of life.
