Clinical Observation of Low Molecular Weight Heparin Calcium in the Prevention of Venous Thromboem-bolism of ICU Patients
10.6039/j.issn.1001-0408.2016.20.33
- VernacularTitle:低分子肝素钙预防ICU患者静脉血栓栓塞症的临床观察
- Author:
Zhenhui FU
;
Bo REN
;
Qundu ZHAO
- Publication Type:Journal Article
- Keywords:
Low molecular weight heparin calcium;
ICU;
Venous thromboembolism;
Safety;
Efficacy
- From:
China Pharmacy
2016;27(20):2838-2840,2841
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the safety and therapeutic efficacy of low molecular weight heparin calcium in the preven-tion of venous thromboembolism (VTE) of ICU patients. METHODS:572 VTE patients were randomly divided into trial group and control group,with 286 cases in each group. Trial group was given Low molecular weight heparin calcium injection 0.3-0.6 ml, im,qd;control group was given Rivaroxaban tablet 10 mg,po,qd. The incidence of VTE,platelet count,coagulation function, quality score of life and the occurrence of ADR were compared between 2 groups. RESULTS:The incidence of VTE in trial group (0.3%)was significantly lower than control group(2.1%),with statistical significance(P<0.05). There was no statistical signifi-cance in platelet count,prothrombin time,APPT, fibrinogen and other indexes between 2 groups before and after treatment(P>0.05). The physical health,body function and role,general health,emotional role function,mental health and other aspects of trial group were improved significantly,compared to control group,with statistical significance(P>0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Low molecular weight heparin calcium can effectively prevent VTE and improve the quality of life, while doesn’t influence platelet count and coagulation function with good safety.
