Efficacy Observation of Amlodipine Besylate Combined with Xinkeshu in the Treatment of Hypertension
10.6039/j.issn.1001-0408.2016.15.13
- VernacularTitle:苯磺酸氨氯地平联合心可舒治疗高血压的临床观察
- Author:
Gang CHEN
;
Min SONG
;
Xiaodong SUN
- Publication Type:Journal Article
- Keywords:
Amlodipine besylate;
Xinkeshu;
Hypertension;
Efficacy;
Safety
- From:
China Pharmacy
2016;27(15):2054-2055,2056
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of amlodipine besylate combined with Xinkeshu in the treatment of hypertension. METHODS:100 patients with hypertension were randomly divided into control group (50 cases) and observation group(50 cases). Control group was orally given one Amlodipine besylate tablet,once a day;observation group was additionally given 4 Xinkeshu tablets,3 times a day. The treatment course was 8 weeks. Clinical efficacy,systolic blood pressure(SBP)and di-astolic blood pressure(DBP)before and after treatment in 2 groups were observed,the incidence of adverse reactions was record-ed. RESULTS:The total effective rate in observation group was significantly higher than control group,the incidence of adverse re-actions was significantly lower than control group,the differences were statistically significant (P<0.05). Before treatment,there were no significant differences in the SBP and DBP between 2 groups (P>0.05). After treatment,the SBP and DBP in 2 groups were significantly lower than before,the differences were statistically significant(P<0.05);but there was no significant difference between 2 groups (P>0.05). CONCLUSIONS:The efficacy of amlodipine besylate combined with Xinkeshu is superior to amlo-dipine besylate alone in the treatment of hypertension,with better safety.
