The Significance of bcl-2 and P53 Expressions in the Papillary Thyroid Cancer.
10.16956/kjes.2007.7.4.231
- Author:
Woong Bae JI
1
;
Jeoung Won BAE
;
Sang Uk WOO
;
Gil Soo SON
;
Jae Bok LEE
;
Bum Whan KOO
;
Yang Seok CHAE
Author Information
1. Department of Surgery, Korea University College of Medicine, Seoul, Korea. kujwbae@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Papillary thyroid cancer;
Prognostic factor;
bcl-2;
P53
- From:Korean Journal of Endocrine Surgery
2007;7(4):231-236
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Papillary thyroid cancer (PTC) has a good prognosis, and it's known to be related to the apoptosis of papillary thyroid cancer. The expression of bcl-2 is thought to be associated with the inhibition of apoptosis. We evaluated the differences of bcl-2 and P53 between PTC and the control (normal tissue and benign lesion). We then analyzed the correlation between the bcl-2 and P53 expressions and the classic prognostic factors. METHODS: Between January 2001 and December 2005, 30 patients who underwent total thyroidectomy for the PTC were included in this study and immunohistochemical staining was performed on the tumors. RESULTS: bcl-2 was expressed in 18 cases (60%) in their PTC (P<0.05). The expression of P53 was not significantly related with the clinicopathological factors, but P53 was expressed in 9 cases (30%) of PTC (P<0.05). The positive staining for was noted in 18 cases (62.1%) of the PTC tissue among the 30 patients, and as the TNM stage progresses, the expression rate of was significantly decrease for 7 stage I cases (100%), for 4 stage ll cases (80%) and for 7 stage ll cases (38.9%). CONCLUSION: bcl-2 was expressed more as the TNM stage of PTC decreases. So bcl-2 is possibly useful as a prognostic factor for PTC, but further studies are needed for confirming its significance.
