Preparation and Quality Evaluation of Propylthiouracil Solid Lipid Nanoparticles
10.6039/j.issn.1001-0408.2016.07.25
- VernacularTitle:丙基硫氧嘧啶固体脂质纳米粒的制备与质量评价
- Author:
Xiongbo XU
;
Yemei CUI
;
Hongjuan SONG
;
Zhenjun PU
;
Qingsong ZHANG
;
Jing TANG
;
Ning MA
- Publication Type:Journal Article
- Keywords:
Propylthiouracil;
Solid lipid nanoparticicles;
Encapsulation efficiency;
in vitro release;
Orthogonal test
- From:
China Pharmacy
2016;27(7):946-948,949
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the formulation and preparation technology of Propylthiouracil(PTU)solid lipid nanopar-ticles(PTU-SLN)and to evaluate the quality of PLN-SLN. METHODS:PTU-SLN was prepared by emulsion ultrasound dispersing method. The formulation of PTU-SLN was optimized by orthogonal design with the entrapment efficacy and particle size as index, using the amount of lipid material,soybean lecithin and poloxamer 188 and ultrasonic time as factors. The quality of prepared nanoparticles was evaluated with particle size,Zeta potential,entrapment efficiency,stability and in vitro drug release rate as in-dex. RESULTS:The optimal formulation and technology was as follows as lipid material 0.6 g,soybean lecithin 1.0 g,poloxamer 188 0.8 g,ultrasonic time 10 min. The obtained PTU-SLN was round and smooth in appearance and distributed evenly in particle size with average particle size of 93.5 nm,Zeta potential of -30.8 mV and average entrapment efficiency of 74.9%. Prepared nanoparticles had no significant change after placing for 15 d at 4 ℃. Accumulative release rate of PTU-SLN was 56.1% at 4 hour in vitro and reached 98.4% at 24 hour. CONCLUSIONS:PTU-SLN is prepared successfully and reasonable in technology,and can reach sustained-release effects.
