Clinical Observation of Clotrimazole Vaginal Tablet in the Treatment of Pregnancy with Vulvovaginal Candi-diasis
10.6039/j.issn.1001-0408.2016.06.15
- VernacularTitle:克霉唑阴道片治疗妊娠合并念珠菌性阴道炎的临床观察
- Author:
Jinying LAI
;
Yan FENG
- Publication Type:Journal Article
- Keywords:
Clotrimazole vaginal tablet;
Vulvovaginal candidiasis;
Pregnancy;
Efficacy;
Safety
- From:
China Pharmacy
2016;(6):763-764,765
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of Clotrimazole vaginal tablet in the treatment of pregnancy with vulvovaginal candidiasis. METHODS:106 pregnant patients with vulvovaginal candidiasis were randomly divided into observation group (56 cases) and control group (50 cases). Observation group was given one tablet Clotrimazole vaginal tablet,washed the genital area before treatment to keep clean and one Clotrimazole vaginal tablet was sent to intravaginal 5-6 cm,once every 2 day. Control group was given Lactobacillus vaginal capsule,once a day,washed the genital area before treatment and one Lactobacillus vaginal capsule was sent to intravaginal 5-6 cm. The treatment course for both groups was 8 d. No sexual activities during treatment and no other drugs. Clinical efficacy,clearance rate of candidiasis,pregnancy and incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate and clearance rate of candidiasis in observation group were significantly higher than control group,carrier rate was significantly lower than control group,the differences were statistically significant (P<0.05). And there were no significant differences in the pregnancy and incidence of adverse reactions between 2 groups (P>0.05). CONCLU-SIONS:Clotrimazole vaginal tablet shows significant efficacy in the treatment of pregnancy with vulvovaginal candidiasis and can clear candidiasis,with good safety.
