Differential diagnosis value of borderline ovarian tumor and stage I epithelial ovarian cancer:using MRI combined with tumor markers
10.3760/cma.j.issn.1008-6706.2016.22.026
- VernacularTitle:磁共振成像联合肿瘤标志物对卵巢交界性肿瘤与Ⅰ期上皮性卵巢癌的诊断价值
- Author:
Jie LIU
;
Haidong LIU
;
Yuanjing HU
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Magnetic resonance imaging;
Tumor markers;
Diagnosis,differential
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(22):3460-3463,3464
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of MRI combined with tumor markers in the differential diagnosis of borderline ovarian tumor(BOT)and stage I epithelial ovarian carcinoma(EOC),increase the rate of preoperative diagnosis.Methods Fifty -six patients with BOT(BOT group)and forty -seven patients with stage I EOC(EOC group)confirmed pathologically underwent tumor markers and MRI examination were selected.The MRI imaging features and tumor markers level were compared between the two groups.Results BOTand EOC group onset age were (39.45 ±11.83),(44.38 ±12.44)years old respectively,two groups had statistically significant difference(t =2.05,P <0.05).The location of tumor,size,number of septation had no differences between the two groups(all P >0.05).However,the solid components were larger (76.0 ±54.9)mm and the septations were thicker (6.2 ± 3.5)mm in EOC group than in BOT group (49.0 ±47.2)mm,(3.6 ±3.5)mm(t =-2.642,-3.784,all P <0.05),and solid components and thick septations were more frequently seen in EOC group(59.6%)than 37.5% in BOT group(χ2 =4.992,P <0.05).The serum CA125 and CA199 levels between the two groups had no statistically significant differences(all P >0.05).The serum HE4 levels between BOT group[(86.9 ±82.2)pmol/L]and EOC group[(166.3 ±87.1)pmol/L]had statistically significant difference (t =-4.723,P <0.05).MRI prompt tumors maximum diameter and thickness of the separated solid ingredients combined serum HE4 levels to identify two groups of AUC of the tumor and its sensitivity,specificity were 0.820,72.3%,80.4%,respectively.Conclusion The fea-tures like younger,increased solid components,thickened septum and higher serum HE4 level may be helpful in the differential diagnosis of BOT and stage I EOC.
