The function of entecavir to Mig in patients with chronic hepatitis
10.3969/j.issn.1673-4130.2016.19.001
- VernacularTitle:恩替卡韦对乙型肝炎患者干扰素诱导单核因子作用
- Author:
Lixia ZHANG
- Publication Type:Journal Article
- Keywords:
chronic hepatitis B;
γ-interferon induced monokine;
entecavir
- From:
International Journal of Laboratory Medicine
2016;37(19):2661-2662,2666
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the function of entecavir to γ‐interferon induced monokine(Mig) for chronic hepatitis B pa‐tients .Methods The 40 cases of chronic hepatitis B patients were treated with entecavir tablet .The Mig level were detected by ELISA in 40 patients in the time before and after treatment of 12 weeks and 24 weeks ;HBsAg ,HBeAg level were analyzed by using electrochemiluminescence and HBV‐DNA was tested by using real‐time quantitative PCR (FQ‐PCR) .Results Mig and HBsAg , HBeAg ,HBV DNA levels were significantly lower than before treatment in the 40 patients(P< 0 .05) .Compared with those in the time of 12 weeks after treatment ,those indexes after treatment 24 weeks were significantly decreased(P< 0 .05) .Conclusion Ente‐cavir treatment can reduce the level of Mig ,HBsAg and HBeAg ,HBV DNA ,and help to control disease progression in chronic hep‐atitis B .
