Clinical Effects of Shark Cartilage Extracts on Erythematotelangiectatic Rosacea Patients.
- Author:
Tae Young HAN
1
;
Beom Joon KIM
;
Myeung Nam KIM
;
Chang Hun HUH
;
Nark Kyoung RHO
;
Soo Hong KIM
;
Hyuck Ki HONG
;
Yeon Shik CHOI
;
Young Chang JO
Author Information
1. Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea. beomjoon@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Rosacea;
Shark cartilage extracts
- MeSH:
Bites and Stings;
Cartilage*;
Erythema;
Flushing;
Humans;
Matrix Metalloproteinase Inhibitors;
Photography;
Rosacea*;
Sensation;
Sharks*;
Telangiectasis
- From:Korean Journal of Dermatology
2007;45(12):1253-1257
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Persistent facial telangiectasia, erythema and flushing are the major cosmetic problems in patients with rosacea. However various therapeutic treatments for rosacea papules and pustules are not effective in reducing telangiectasia and flushing reactions. Matrix-centered theory that dermal matrix degradation can cause telangiectasis, erythema and flushing, is one of the various theories of rosacea pathogenesis. Shark cartilage extracts are collagenase inhibitors and can inhibit dermal matrix degradation. OBJECTIVE: The purpose of this study was to evaluate the clinical effects of shark catilage extracts (Venatrix(R)) for erythematotelangiectatic rosacea patients. METHODS: Twenty three patients with erythematotelangiectatic rosacea applied shark cartilage extracts twice daily for up to 8 weeks. Efficacy was evaluated by erythema index using mexameter (MPA 5, CK, Germany) and clinical photography. RESULTS: Erythema index decreased from 525.7+/-114 to 413.9+/-101.7 (mean reduction: 21.3%) (p<0.1) after 8 weeks treatment. 16 patients (69%) showed excellent or good results by clinical photography. Transient stinging sensation was the most common adverse effect and these symptoms improved after the first few days. There were no other significant side effects. CONCLUSION: Shark cartilage extracts may be an effective treatment for mild erythematotelangiectatic rosacea.
