Pharmacogenetics of individualized treatment of asthma
10.3760/cma.j.issn.1673-4408.2016.09.003
- VernacularTitle:哮喘个体化治疗的药物遗传学
- Author:
Xiaoyuan JING
;
Min LU
- Publication Type:Journal Article
- Keywords:
Asthma;
Individualized treatment;
Pharmacogenetics
- From:
International Journal of Pediatrics
2016;43(9):673-676,714
- CountryChina
- Language:Chinese
-
Abstract:
Asthma, a complex polygenetic disease, has individual differences in patient′s response to asthma drugs,which is mainly related to gene polymorphism. These genes include beta 2-adrenaline receptor genes(ADRB2),the glucocorticoid receptor genes(NR3C1) and leukotriene synthase genes(LTC4S and ALOX5),etc. Pharmacogenomics can realize individualized treatment of asthma,reduce the admission rate and the mortality rate,and reduce the cost of treatment. Pharmacogenomics of children asthma is reviewed in this arti-cle,hoping to provide help for the individualized treatment of asthma.
