Meta-analysis of the Efficacy of L-carnitine in the Treatment of Heart Failure
10.6039/j.issn.1001-0408.2016.27.25
- VernacularTitle:左卡尼汀治疗心力衰竭疗效的Meta分析
- Author:
Xinlu WANG
;
Yadan CHEN
;
Xiujuan FU
- Publication Type:Journal Article
- Keywords:
L-carnitine;
Heart failure;
Meta-analysis;
Randomized controlled trial
- From:
China Pharmacy
2016;27(27):3818-3820,3821
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the efficacy of L-carnitine in the treatment of heart failure,and provide evi-dence-based reference for clinical treatment. METHODS:Retrieved from Cochrane Library,PubMed,Medline,CJFD and Wanfang Database, randomized controlled trials(RCT)about the efficacy of L-carnitine in the treatment of heart failure were collected. Me-ta-analysis was performed by using Rev Man 5.1 software after data extraction and quality evaluation. RESULTS:Totally 42 RCTs were enrolled,involving 3 494 patients. Results of Meta-analysis showed,L-carnitine can significantly improve the effective rate [OR=4.07,95%CI(3.16,5.25),P<0.001],increase left ventricular ejection fraction(LVEF)[MD=4.49,95%CI(3.49,5.49),P<0.001],decrease brain natriuretic peptide(BNP)levels [MD=-130.17,95%CI(-193.81,-66.52),P<0.001] and improve walk-ing distance in 6 minutes [MD=46.12,95%CI(35.72,56.51),P<0.001],the differences were statistically significant. CONCLU-SIONS:L-carnitine has good efficacy in the treatment of heart failure,it can significantly improve LVEF,decrease BNP level and increase walking distance in 6 minutes.
