Efficacy and Safety of Bushen Huoxue Herb versus Celecoxib in the Treatment of Knee Osteoarthritis:A Me-ta-analysis
10.6039/j.issn.1001-0408.2016.27.23
- VernacularTitle:补肾活血中药对比塞来昔布治疗膝骨性关节炎疗效与安全性的Meta分析
- Author:
Guihong LIANG
;
Zujian LIANG
;
Yongkai LIN
;
He SUN
;
Yuxin HUANG
;
Jun YI
- Publication Type:Journal Article
- Keywords:
Knee osteoarthritis;
Bushen huoxue herb;
Celecoxib;
Randomized control trial;
Meta-analysis
- From:
China Pharmacy
2016;27(27):3810-3813,3814
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the efficacy and safety of Bushen huoxue herb and celecoxib in the treat-ment of knee osteoarthritis, and provide evidence-based reference for clinical treatment. METHODS:Retrieved from CNKI, CBM,VIP and Wanfang Database,Medline,PubMed and Cochrane Library,randomized controlled trials (RCT) about Bushen huoxue herb(test group)and celecoxib(control group)in the treatment of knee osteoarthritis were collected. Meta-analysis was per-formed by using Rev Man 5.3 software after data extraction and quality evaluation. RESULTS:Totally 15 RCTs were included,in-volving 1 129 patients. Results of Meta-analysis showed,the total effective rate [RR=1.09,95%CI(1.04,1.14),P<0.01] and visu-al ache(VAS)score [MD=-0.49,95%CI(-0.94,-0.03),P<0.05] in test group were significantly higher than control group, the differences were statistically significant;there was no significant difference in knee function score [Lequesne:MD=0.24,95%CI (-1.20,1.68),P>0.05;Lysholm:MD=2.32,95%CI(-1.95,6.58),P>0.05;WOMAC:MD=-2.87,95%CI(-6.38,0.64), P>0.05] and the incidence of adverse reactions in 2 groups[RR=0.49,95%CI(0.22,1.09),P=0.08]. CONCLUSIONS:Bushen huoxue herb shows better efficacy and analgesic effect than celecoxib in the treatment of knee osteoarthritis,and is similar to cele-coxib in terms of improving knee function score and safety.
