Content Determination of Paracetamol by the Nonlinear Quantitative Model with Infrared Spectroscopy
10.6039/j.issn.1001-0408.2016.27.35
- VernacularTitle:非线性建模红外光谱法测定对乙酰氨基酚原料药的含量Δ
- Author:
Lanlan QIU
;
Mingmei LI
- Publication Type:Journal Article
- Keywords:
Paracetamol;
Nonlinear model;
Infrared spectrum;
Content determination
- From:
China Pharmacy
2016;27(27):3850-3851,3852
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide theoretical basis for the detection of paracetamol by infrared spectroscopy. METHODS:0.002-0.02 g paracetamol was accurately weighed,added into 0.2 g potassium bromide,respectively,fully ground and well mixed, potassium bromide pressing plate method was used for to-be-tested test sample. Using hollow cathode lamp as light,scanning fre-quency was 30 times,resolution was 0.5 cm-1,scan range was 4000-400 cm-1,infrared absorption spectrum was determined and recorded to select the characteristic absorption peaks,then determine the optimized characteristic absorption peaks. Linear and non-linear models were respectively established by using mathematics modeling methods. RESULTS:1 016 cm-1 absorption peak with weaker absorbance but stronger features was selected for the analysis. According to the model establishing and calculation,the accu-racy of the nonlinear model was much higher than the linear model,r=0.942. CONCLUSIONS:Nonlinear quantitative model for quantitatively determining the content of paracetamol is feasible,and suitable for the on-destructive and rapid on-line quality control of paracetamol.
