Study on the Improving the Quality Standard for Compound Pediatric Anticough Oral Solution
10.6039/j.issn.1001-0408.2016.27.37
- VernacularTitle:复方小儿止咳口服溶液的质量标准提高研究
- Author:
Minxin ZHANG
;
Aiwen HUANG
;
Hongtao SONG
- Publication Type:Journal Article
- Keywords:
Compound pediatric anticough oral solution;
Quality standard;
TLC;
HPLC
- From:
China Pharmacy
2016;27(27):3855-3856,3857
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize and improve the quality standard for Compound pediatric anticough oral solution. METH-ODS:TLC was adopted for the qualitative identification of Glycyrrhiza uralensis;chemical reaction was adopted for the qualitative identification of ipecac tincture,ammonium chloride;and HPLC was adopted for the content determination of ammonium glycyrrhi-zinate:the column was Agilent Zorbax XDB C18 with mobile phase of acetonitrile-0.2 mol/L ammonium acetate(20∶80,V/V)at a flow rate of 1.0 ml/min,the detection wavelength was 250 nm,column temperature was 30℃,and the injection volume was 10 μl. RESULTS:TLC spots of G. uralensis were clear and well-separated,negative control without interference. Differential response of ipecac tincture and ammonium chloride showed significant positive characteristics. The linear range of ammonium glycyrrhizinate was 6.08-72.96 μg/ml (r=0.999 9);RSDs of precision,stability and reproducibility tests were lower than 1.0%;recovery was 99.69%-100.28%(RSD=0.20%,n=6). CONCLUSIONS:Optimizing and improving the standard are helpful for the quality con-trol of Compound pediatric anticough oral solution.
